Endometrial biopsies are a fairly common minor procedure performed in many gyn offices when patients are experiencing heavy painful periods. The technique involves sticking a needle into the uterine lining to obtain a small tissue sample; it can be very painful and often produces inconclusive information. Blind biopsies, via either needle or currette, can very easily completely miss the area in question, rendering an inaccurate outcome. When dealing with fibroids and adenomyosis, biopsies of the lining do not render any information as to the make up of the tumors. The biopsy is strictly giving information about the uterine lining. The procedure is rather like sticking an needle in an orange to try to locate a seed…..probably not successful. If you have fibroids, or adenomyosis, taking a blind biopsy of endometrial tissue does not render a conclusive diagnosis about your disease….