This is a medication routinely used to reduce heavy bleeding associated with fibroid tumor disease. As a secondary benefit it will temporarily shrink fibroids due to its anti-estrogen effect. Basically, this injection reduces estrogen production by the ovaries, and should be limited to a 6 months course of treatment. Symptoms associated with Lupron can be the same as menopause…hot flashes, depression, difficulty sleeping, and headaches. Once discontinuing the drug, the ovaries should once again begin to produce estrogen resulting in regrowth of fibroids. Lupron is a “temporary fix” and does not produce long term positive results.